CO-MED will test whether two different medications when given in combination as the first treatment step, compared to one medication, will enhance remission rates, increase speed of remission, be tolerable, and provide better sustained benefits in the longer term. JOHNSON, British MedicalJournal, 1971, 3, 495-500 Summary Depression, headaches, and libido were rated in 272 women before starting a contraceptive method and at intervals during the first year ofuse-54were fitted with anintrauterine device (I. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
60,61 At a somewhat later stage, a larger panel of CYPs will be investigated and the effect of the CYP specific inhibitors can be studied on each metabolic.
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